Education

• Ph.D.-(2003-2008; Chemistry)

Submission-2007 at ‘Swami Ramanand Teerth Marathwada University, Nanded.’ Research at ‘Indian Institute of Chemical Technology, Hyderabad.’

• M.Sc.-(1998-2000; Chemistry)

Swami Ramanand Teerth Marathwada University, Nanded, Maharashtra.

• B.Sc.-(1995-1998; Chemistry, Analytical Chemistry, Physics)

Science College, Nanded, Maharashtra. (S. R. T. M. University, Nanded)

Teaching, Research & Industrial Experience

TEACHING EXPERIENCE

Sept 2012- Assistant Professor, Centre for Chemical & Pharmaceutical Sciences, Central University of Punjab, Bathinda, Punjab.

Nov 2002-Jun 2003: Physical Chemistry Lab. Instructor for B.Tech.-Ist yr & worked as Researcher at Institute of Chemical Technology, Mumbai (Formerly UDCT)

POST DOCTORAL RESEARCH

May 2009- Dec 2011: Advisor: Prof. Ronald J. Quinn; Director - Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Australia. (Drugs for Neglected Diseases Initiative, Project)

‘Natural product based Drug Discovery against Tropical diseases and Inflammation’

May 2007- Feb 2009: Advisor: Prof. Heonjoong Kang; Director- Center for Marine Natural Products & Drug Discovery, Seoul National University, Seoul, South Korea.

‘Antibacterial Marine Natural product synthesis and Drug Discovery against Metabolic diseases like obesity, type II diabetes’

DOCTORAL RESEARCH

Aug 2003 - May 2007: Advisor: Dr. Biswanath Das (FRS); Deputy Director- Indian Institute of Chemical Technology, Hyderabad, India.

‘Isolation and structure elucidation of novel anticancer molecules and synthesis of small bioactive heterocyclic molecules using developed synthetic methods’

INDUSTRIAL EXPERIENCE

Aug 2000-Aug 2001: Production officer at VETCARE Organics Pvt. Ltd., Bangalore.

Worked on pilot scale product development of API- Amitraz and Halquinol BP 80.

Acquaintance in GMP, GLP & ISO 9001 regulations.

Research Interests

• Natural product (Terrestrial or Marine) isolation, structure confirmation & synthesis targeting cancer & infectious diseases.

• Natural product inspired synthesis, library generation targeting infectious & Neglected Tropical Diseases.

• Developing new synthetic methods and diversity oriented synthesis.

Awards/ Fellowships

• May 2009 - Dec 2011 Postdoctoral Research Fellowship, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Australia.

• May 2007- Feb 2009 Postdoctoral Research Fellowship, Center for Marine Natural Products and Drug Discovery, Seoul National University, Seoul, South Korea.

• 2003-Awarded Junior & Senior Research Fellowship (UGC- CSIR fellowship) for the period of 5 years for Ph.D. (Aug 2003-2008)

• 2002- Qualified NET- LS (CSIR-UGC) examination.

• 2002- Qualified SET (Maharashtra State Eligibility Test for Lectureship conducted by University of Pune, accredited by UGC) examination.

• 2002- Awarded G. D. Gokhale Charitable Trust Fellowship (4 yrs) for research at Institute Of Chemical Technology (Formerly UDCT), Mumbai.

Languages

Hindi, Marathi, Kannada and English

Publications

1. Synthesis of Melicodenine C, D and E. Harish Holla, Ian D. Jenkins, Juliette E. Neve, Rebecca H. Pouwer, Ngoc Pham, Simon J. Teague, Ronald J. Quinn*, Tetrahedron Letters 53, 7101 (2012).

2. Bioactive dihydropyrimidines: An overview. Vivekanand B. Jadhav*, Harish V. Holla, Sunil U. Tekale, Rajendra P. Pawar, Der Chimica Sinica, 3(5), 1213 (2012). (Review)

3. Discovery, design and synthesis of Y-shaped peroxisome proliferator-activated d receptor agonists as potent anti-obesity agents in vivo. Hoosang Hwang, Jungyeob Ham, Jaeyoung Ko, Sun Jin Cho, Harish Holla, Joydeep Banerjee, Sukho Kim, Inho Yang, Sang-Jip Nam, Hyukjae Choi, Woojin Lee, Chaok Seok, Jungwook Chin, Heonjoong Kang*, European Journal Of Medicinal Chemistry, 53, 190 (2012).

4. Synthesis of antitrypanosomal 1,2-dioxane derivatives based on a natural product scaffold. Harish Holla, Mehdi Labaied, Ngoc Pham, Ian D. Jenkins, Kenneth Stuart, Ronald J. Quinn*, Bioorg. Med. Chem. Lett., 21, 4793 (2011). [Citation-1]

5. Novel cytotoxic constituents of Orthosiphon diffusus. Harish Holla, Yallamalla Srinivas, Anjoy Majhi, Gannoju Srinivasulu, Balasubramain Sridhar, Arepalli Sai Krishna, Janapala Venkateshwara Rao, Biswanath Das*, Tetrahedron Letters, 52, 49 (2011). [Citation-1]

6. Stereoselective synthesis of the non-quinonoid part of isoarnebifuranone and efforts toward the synthesis of isoarnebifuranone. Biswanath Das*, Harish Holla, Yallamalla Srinivas, Sudhakar, C, Ind. J. Hetero. Chem. 18, 145 (2008). [Citation-1]

7. Efficient (bromodimethyl)sulfonium bromide mediated synthesis of benzimidazoles. Biswanath Das*, Harish Holla, Yallamalla Srinivas, Tetrahedron Lett., 48, 61 (2007). [Citation-66]

8. An expedient stereoselective synthesis of (Z) and (E) - allyl iodides from Baylis-Hillman adducts along with selective iodination of benzylic alcohols using polymethylhydrosiloxane-iodine system. Biswanath Das*, Harish Holla, Yallamalla Srinivas, Nikhil Chowdhury, B. P. Bandgar, Tetrahedron Lett. 48, 3201 (2007). [Citation-12]

9. Mild and efficient reduction of 2-isoxazolines using NaBH4-NiCl2.6H2O and convenient preparation of N-Boc protected 1,3-aminols and a potentially bioactive tetracyclic heterocycle. Biswanath Das*, Harish Holla, Yallamalla Srinivas, Katta Venkateswarlu, Ind. J. Hetero. Chem. 17, 1(2007). [Citation-2]

10. Synthesis of 3,5-Disubstituted isoxazoles Using Hypervalent Iodine. Biswanath Das*, Harish Holla, Ponnaboina Tirupathi, Katta Venkateswarlu, Ind. J. Hetero. Chem. 17, 173 (2007). [Citation-1]

11. An efficient synthesis of benzyl bromides from aromatic aldehydes using polymethylhydrosiloxane and (bromodimethyl)sulfonium bromide or N-bromosuccinimide. Biswanath Das*, Yallamalla Srinivas, Harish Holla, Laxminarayana Keetha, Ravirala Narender, Tetrahedron Lett. 48, 6681 (2007). [Citation-9]

12. An efficient and facile hydroiodination of alkenes and alkynes using polymethylhydrosiloxane-iodine system. Biswanath Das*, Yallamalla Srinivas, Harish Holla, Ravirala Narender, Chem. Lett. 36, 800 (2007). [Citation-2]

13. Hypervalent iodine-mediated efficient synthesis of imidazoles. Biswanath Das*, Yallamalla Srinivas, Harish Holla, Krishnaiah Maddeboina, Ravirala Narender, Chem. Lett. 36, 1270 (2007). [Citation-6]

14. Remarkably chemoselective reduction of unmodified Baylis-Hillman adducts by InCl3-NaBH4: Application to the stereoselective synthesis of trisubstituted alkenones including two alarm pheromones; Biswanath Das*, Joydeep Banerjee, Nikhil Chowdhury, Anjoy Majhi, Harish Holla, Synlett, 12, 1879 (2006). [Citation-6]

15. A highly chemo selective Boc protection of amines using sulfonic-acid-functionalized silica as an efficient heterogeneous recyclable catalyst. Biswanath Das*, Katta Venkateswarlu, Maddeboina Krishnaiah, Tetrahedron Lett., 47, 7551 (2006). [Citation-27]

16. An efficient, rapid and regioselective nuclear bromination of aromatics and heteroaromatics with NBS using sulfonic acid functionalized silica as a heterogeneous recyclable catalyst. Biswanath Das*, Katta Venkateswarlu, Maddeboina Krishnaiah, Harish Holla, Tetrahedron Lett., 47, 8693 (2006). [Citation-32]

17. An efficient synthesis of 2-benzoxepines from Baylis-Hillman adducts using heterogeneous catalyst. Biswanath Das*, Joydeep Banerjee, Anjoy Majhi, Nikhil Chowdhury, Harish Holla, Kankipati Harakishore, Upadhayula Suryanarayana Murty, Chem. Pharm. Bull., 54, 403 (2006). [Citation-11]

18. Acylated 5,7,2?,6?-oxygenated flavone glycosides from Andrographis alata. Biswanath Das*, R. Ramu, M. Ravinder Reddy, H. Harish, V. Saidi Reddy, K. V. S. Ramakrisna, Y. Koteswar Rao, Phytochemistry, 67, 978 (2006). [Citation-2]

19. A rapid and efficient stereoselective synthesis of (Z) - and (E) - allyl bromides from Baylis-Hillman adducts using bromo(dimethyl)sulfonium Bromide. Biswanath Das*, Katta Venkateswarlu, Maddeboina Krishnaiah, Harish Holla, Anjoy Majhi, Helv.Chem. Acta, 89, 1417 (2006). [Citation-20]

20. Sulfonic acid functionalized silica: a remarkably efficient heterogeneous reusable catalyst for a-monobromination of carbonyl compounds using N-bromosuccinimide. Biswanath Das*, Katta Venkateswarlu, Harish Holla, Maddeboina Krishnaiah, J. Mol. Cat. A: Chem., 253, 107 (2006). [Citation-27]

21. Isomerization of the Baylis-Hillman adducts using Amberlyst-15 as a heterogeneous reusable catalyst: a simple and efficient stereoselective synthesis of (E)-cinnamyl alcohol derivatives. Biswanath Das*, Joydeep Banerjee, Anjoy Majhi, Nikhil Chowdhury, Katta Venkateswarlu, Harish Holla, Indian. J. Chem., 45b, 1729 (2006). [Citation-3]

22. Synthesis of novel spiro- 2-isoxazolines derived from parthenin. Biswanath Das*, Chimmani Ramesh, Nasi Ravindranath, Gurram Mahendar, Harish Holla, Indian J. Chem., 44B, 2149 (2005). [Citation-1]

23. Synthesis of pyrano-and furano quinolines using silica chloride or Amberlyst-15 as a heterogeneous catalyst. Biswanath Das*, M. Ravinder Reddy, Harish Holla, Ravirala Ramu, Katta Venkateswarlu, J. Chem. Res (S), 793 (2005). [Citation-7]

24. Amberlyst -15 catalysed acetylation of heteroaromatics with acetic anhydride under solvent free conditions. Biswanath Das*, Rammohan Pal, Joydeep Banerjee, Gurram Mahendar, Harish Holla, Katta Venkateswarlu, Indian J. Chem., 44B, 198 (2005).

25. Clerodane diterpenoids from Pulicaria wightiana. Biswanath Das*, M. Ravinder Reddy, R. Ramu, N. Ravindranath, H. Harish, K. V. S. Ramakrisna, Y. Koteswar Rao, Phytochemistry, 66, 633 (2005). [Citation-2]

26. An easy access to 3a,4-dihydro-3H-chromeno[4,3-c]isoxazoles and functionalized isoxazolines. Biswanath Das*, Gurram Mahender, Harish Holla, Joydeep Banerjee, ARKIVOC, iii, 27 (2005). [Citation-8]

27. Organic reactions in water: An efficient one-pot synthesis of acyloxiranes from Baylis-Hillmann adducts using hypervalent iodine. Biswanath Das*, Harish Holla, Katta Venkateswarlu, Anjoy Majhi, Tetrahedron Lett., 46, 8895 (2005). [Citation-19]

28. A convenient method for the preparation of Benzopyrano- and furopyrano-2- isoxazoline derivatives using Hypervalent Iodine Reagent. Biswanath Das*, Harish Holla, Gurram Mahender, Katta venkateswarlu, B. P. Bandgar, Synthesis, 10, 1572 (2005). [Citation-14]

29. Hypervalent iodine mediated interaction of aldoximes with activated alkenes including Baylis -Hillman adducts: A new and efficient method for the preparation of nitrile oxide from aldoximes. Biswanath Das*, Harish Holla, Gurram Mahender, Joydeep Banerjee, Majjigapu Ravinder Reddy, Tetrahedron Letters, 45, 7347 (2004). [Citation-32]

30. Synthesis of coumarins via Pechmann condensation using heterogeneous catalysts. Biswanath Das*, Katta Venkateswarlu, Gurram Mahender, Harish Holla, J. Chem. Res. (S), 836 (2004). [Citation-4]

Indicates the corresponding Author

Poster Presentations at Conferences

• Synthetic Applications of Baylis-Hillman Chemistry: Simple accesses to some Important Insect Pheromones, CSIR and ACS Organized International Conference on Advances in Organic Chemistry and Chemical Biology, Biswanath Das, Joydeep Banerjee, Nikhil Chowdhury, Anjoy Majhi and Harish Holla, Indian Institute of Chemical Technology, Hyderabad, (India), 11-12 Jan.- 2006.

• A Facile One-Pot Synthesis of Alkyl aryl Sulfides/Selenides from Aryl halides, 236th ACS National Meeting and Exposition, Jungae tak, Jungwook Chin, Harish Holla, Jungyeob Ham and Heonjoong Kang, Philadelpia (USA), 17-21 Aug-2008.

• Synthesis of Butenolide derivatives - A search for probable drug lead, 3rd CMDD symposium on Marine Natural Product and Drug Discovery, Harish Holla, Jungwook Chin, Hiyoung, Katta Venkateswarlu, Hyunjung Kim, Youngju Lee and Heonjoong Kang, Seoul, (South Korea), 5-7 Nov.-2008.

• Synthesis of antitrypanosomal 1,2-dioxane derivatives based on a natural product scaffold, 27th International Symposium On The Chemistry of Natural Products & 7th International Conference On Biodiversity, Harish Holla, Ngoc Pham, Mehdi Labaied, Ian D. Jenkins, Kenneth Stuart and Ronald J. Quinn, Brisbane, (Australia), 10-15 July-2011.

Oral Presentation/Talk

• Talk at School of Chemical Sciences, Swami Ramanand Teerth Marathwada University, Nanded, (April 2009) ‘ Chemistry a good career option.’

• Presentation at CMDD, Seoul National University, Seoul, South Korea, (15th June 2007) ‘Development and application of new synthetic methodologies for construction of bioactive molecules along with investigation on novel natural anticancer agents.’

• Talk at Eskitis Institute for Cell & Molecular Therapies, Griffith University, Brisbane, Australia, (3rd November 2009) ‘A journey from natural products to synthetic chemistry.’

• Talk at National Institute for Interdisciplinary Science and Technology, Trivandrum, (June 2011) ‘Drug discovery from natural products and synthetic chemistry.’

• Invited talk at 17th International conference by Indian Society of Chemists & Biologists-2012 organized by Solapur University, Solapur, India, (23rd January 2012) ‘Natural product scaffold based lead optimization against Tropical neglected diseases.’