Education

Career Profile

Research Interests / Specialization

Design and Synthesis of novel small heterocycles as anticancer, antimalarial and xanthine oxidase inhibitors.

Synthesis and methodology development of small bioactive molecules.

Teaching Experience (Subjects/Courses Taught)

Organic and Medicinal Chemistry (undergraduate leveland postgraduate level).

Honors & Awards

2001- Gold Medal for standing fist in University in B. Pharmacy Course.

2001- Qualified GATE in pharmaceutical sciences (All India 30th Rank; 99.08 percentile)

2001- NIPER fellowship during M. S. (Pharm) programme

2002- Qualified LS UGC-NET in chemical sciences

2003-2007- DST Fellowship during PhD programme

Most cited paper award 2005-2008 and 2004-2007 for tetrahedron Letters 2005, 46, 1721-1724

Publications

1)Nepali, K; Agarwal, A.; Sapra, S.; Mittal, V.; Kumar, R.*;. Banerjee, U. C.; Gupta, M. K., Satti, N. K.; Suri, O. P.; Dhar, K. L. N-(1,3-diaryl-3-oxopropyl)amides as a new template for xanthine oxidase inhibitors. Bioorg. Med. Chem. 2011, 19, 5569-5576

 2)Kumar, R*, Darpan, Sharma, S., Singh, R. Xanthine oxidase inhibitors: A patent survey Expt. Opin. Ther. Pat. Invited review. DOI:10.1517/13543776.2011.577417.

3) Nepali, K; Singh, G.; Turan, A.; Agarwal, A.; Sapra, S., Kumar, R.*; . Banerjee, U. C.; Satti, N. K.; Gupta, M. K., Suri, O. P., Dhar, K. L. A rational approach for the design and synthesis of 1-acetyl-3,5-diaryl-4,5-dihydro(1H)pyrazoles as a new class of potential non-purine xanthine oxidase inhibitors. Bioorg. Med. Chem. 2011, 19, 1950-1958.

4) Kumar, N.; Nepali, K; Sapra, S., Bijjem, K. R. V.; Kumar, R.*; Suri, O. P., Dhar, K. L. Effect of nitrogen insertion on the antitussive properties of menthol and camphor. Med. Chem. Res. 2011, DOI: 10.1007/s00044-011-9560-1.

5) Kondaskar, A.; Kondaskar, S.; Kumar, R.; Fishbein, J.; Muvarak, N.; Lapidus, R.; Sadowska, M.; Edelman, M.; Bol, G.; Vesuna, F.; Raman, V.; Hosmane, R. Novel, Broad Spectrum Anti-Cancer Agents Containing the Tricyclic 5:7:5-Fused Diimidazodiazepine Ring System. ACS Med. Chem. Lett. 2011, DOI: 10.1021/ml100281b.

6) Sandhu, H. S., Sapra, S., Gupta, M., Nepali, K., Gautam, R., Yadav, S., Kumar, R.*, Jachak, S. M., Chugh, M., Gupta, M. K., Suri, O. P., Dhar, K. L. Synthesis and biological evaluation of arylidene analogues of Meldrum's acid as a new class of antimalarial and antioxidant agents. Bioorg. Med. Chem. 2010, 18, 5626-5633.

7) Sapra S., Nepali, K., Kumar, R, Goyal, R., Suri, O. P., Koul, V. K., Dhar, K. L Int. J. Pharm. Sci. Res. 2010, 1, 53-55 (ISSN: 0975-8232).

8) Chakraborti, A. K., Garg, S. K., Kumar, R., Motiwala, H. F. and Jadhavar, P. S. Progress in COX-2 Inhibitors: A Journey So Far. Curr. Med. Chem. 2010, 17, 1563-1593.

9) Kumar, R. Ujjinamatada, R. K. and Hosmane, R. S. The First Synthesis of a Novel 5:7:5-Fused Diimidazodiazepine Ring System and Some of its Chemical Properties. Org. Lett. 2008, 10, 4681-4684.

10) Sharma, G., Kumar, R. and Chakraborti, A. K. “On Water” synthesis of 2,4-diaryl-2,3-dihydro-1,5-benzothiazepines catalysed by sodium dodecyl sulphate (SDS). Tetrahedron Lett. 2008, 49, 4269-4271.

11) Sharma, G., Kumar, R. and Chakraborti, A. K. Fluoroboric acid adsorbed on silica-gel (HBF4-SiO2) as a new, highly efficient and reusable heterogeneous catalyst for thia-Michael addition to a,ß-unsaturated carbonyl compounds. Tetrahedron Lett. 2008, 49, 4272-4275.

12) Kumar, D., Kumar, R. and Chakraborti, A. K. Tetrafluoroboric Acid Adsorbed on Silica Gel as a Reusable Heterogeneous Dual-Purpose Catalyst for Conversion of Aldehydes/Ketones into Acetals/Ketals and Back Again. Synthesis 2008, 1249-1256.

13) Motiwala, H. F., Kumar, R. and Chakraborti, A. K. Microwave-Accelerated Solvent- and Catalyst-free Synthesis of 4-Aminoaryl/alkyl-7-chloroquinolines and 2-Aminoaryl/alkylbenzothiazoles. Aust. J. Chem. 2007, 60, 369-374.

14) Khatik, G. L., Kumar, R. and Chakraborti, A. K. Magnesium Perchlorate as a New and Highly Efficient Catalyst for the Synthesis of 2,3-Dihydro-1,5-benzothiazepines. Synthesis, 2007, 0541-0546. Cited 4 times.

15) Kumar, R., Kumar, D., and Chakraborti, A. K. Perchloric Acid Adsorbed on Silica-Gel (HClO4-SiO2) as an Inexpensive, Extremely Efficient and Reusable Dual Catalyst System for Acetal Formation and their Deprotection to Aldehydes/Ketones. Synthesis, 2007, 0299-0303. Cited 5 times.

16) Khatik, G. L., Sharma, G., Kumar, R. and Chakraborti, A. K. Scope and Limitations of HClO4-SiO2 as an Extremely Efficient, Inexpensive, and Reusable Catalyst for Chemoselective Carbon-Sulfur Bond Formation. Tetrahedron, 2007, 63, 1200-1210. Cited 10 times.

17) Bhutani, H., Singh, S., Vir, S., Bhutani, K. K., Kumar, R., Chakraborti, A. K. and Jindal K. C. LC and LC-MS study of stress decomposition behaviour of isoniazid and establishment of validated stability-indicating assay method. J. Pharm. Biomed. Anal. 2007, 43, 1213-1220. Cited 1 time.

18) Sharma, G., Kumar, R. and Chakraborti, A. K. A Novel Environmentally Friendly Process for Carbon-Sulfur Bond Formation Catalyzed by Montmorillonite Clays. J. Mol. Cat. A: Chem. 2007, 263, 143-148. Cited 5 times.

19) Khatik, G. L., Kumar, R. and Chakraborti, A. K. Catalyst-Free Conjugated Addition of Thiols to a,ß -Unsaturated Carbonyl Compounds in Water. Org. Lett. 2006, 8, 2433-2436. Cited 20 times.

20) Kumar, R., Thilagavathi, R., Gulhane, R. and Chakraborti, A. K. Zinc(II) perchlorate as a new and highly efficient catalyst for formation of aldehyde 1,1-diacetate at room temperature and under solvent-free conditions. J. Mol. Cat. A: Chem. 2006, 250, 227-232. Cited 6 times.

21) Kumar, R., Spotlight 149: Cu(BF4)2•xH2O: A Versatile Catalyst. Synlett 2006, 0327-0328.

22) Kumar, R., Selvam, C., Kaur, G. and Chakraborti, A. K. Microwave-Assisted Direct Synthesis of 2-Substituted Benzoxazoles from Carboxylic Acids under Catalyst and Solvent-Free Conditions. Synlett 2005, 1401-1404.Cited 6 times.

23 ) Kumar, R., and Chakraborti, A. K. Copper (II) tetrafluoroborate as a novel and highly efficient catalyst for acetal formation. Tetrahedron Lett. 2005, 46, 8319-8323. Cited 18 times.

24) Thilagavathi, R., Kumar, R., Aparna, V., Sobhia, M. E., Gopalakrishnan, B. and Chakraborti, A. K. Three-dimensional quantitative structure (3-D QSAR) activity relationship studies on imidazolyl and N-pyrrolyl heptenoates as 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) inhibitors by comparative molecular similarity indices analysis (CoMSIA). Bioorg. Med. Chem. Lett. 2005, 15, 1027-1032.

25) Garg, S. K., Kumar, R. and Chakraborti, A. K. Zinc Perchlorate Hexahydrate Catalysed Conjugate Addition of Thiols to a,ß -Unsaturated Ketones. Synlett 2005, 1370-1374. Cited 34 times.

26) Garg, S. K., Kumar, R. and Chakraborti, A. K. Copper (II) tetrafluoroborate as a novel and highly efficient catalyst for Michael addition of mercaptans to a,ß-unsaturated carbonyl compounds. Tetrahedron Lett. 2005, 46, 1721-1724. Cited 43 times (Most Cited Paper 2004-2007 and 2005-2008 Awards).

27) Chakraborti, A. K., Thilagavathi, R. and Kumar, R. Copper (II) Tetrafluoroborate-Catalyzed Formation of Aldehyde-1,1-diacetates. Synthesis 2004, 0831-0833. Cited 29 times.

*Indicates the corresponding author

Languages

Hindi (Native Language), Punjabi and English.

Patents

 1) Title: Novel 5:7:5 Fused Tricyclic Heterocycles and Nucleosides with Potential Anticancer and Antiviral Properties. Inventors: Hosmane, R. S., Kumar, R., Ujjinamatada, R., Provisional US patent, International application no. PCT/US2009/005273. Published and available online.

 2) Title: Novel Cyclooxygenase-2 Inhibitors. Inventors: Chakraborti, A. K. Banerjee, U. C., Kumar, R., Garg, S. K., Meena, V. S., Indian patent, application no. 638/DEL/2008 filed on 14th March 2008.

3) Title: Inhibitors of Phosphodiesterase Type-IV: Benzimidazolone series. Inventors: Chakraborti, A. K. Sarin, S., Rudrawar, S., Kumar, R., Chankeshwara, S. V., Dastidar, S., Ray, A. European patent, application no. 08151539.7-2117, filed on 15th February 2008. US patent, application no. 12/031842, filed on 15th February 2008, United States Patent 20080207659

4) Title: Phosphodiesterase-4 Inhibitors: Urea, Carbamate and Amide series. Inventors: Chakraborti, A. K. Sarin, S., Rudrawar, S., Kumar, R., Chankeshwara, S. V., Dastidar, S., Ray, A. Indian patent, application no. 565/DEL/2006, filed on 3rd March 2006.

5) Title: Phosphodiesterase-4 Inhibitors: Sulphur and Amino series. Inventors: Chakraborti, A. K. Sarin, S., Rudrawar, S., Kumar, R., Chankeshwara, S. V., Dastidar, S., Ray, A. Indian patent, application no. 566/DEL/2006, filed on 6th March 2006.

6) Title: Phosphodiesterase-4 Inhibitors: Fused cyclic urea series. Inventors: Chakraborti, A. K. Sarin, S., Rudrawar, S., Kumar, R., Chankeshwara, S. V., Dastidar, S., Ray, A. Indian patent, application no. 1882/DEL/2006, filed on 22nd August 2006.

Professional Memberships

Life Membership-Indian Pharmacy Graduate Association (IPGA)

Scientific Meetings

 1) Attended 3rd NIPER-(RBL)-CDRI symposium on Medicinal Chemistry and Pharmaceutical Sciences, March 03-05, 2011 held at CDRI Lucknow.

 2) A short term certificate course (from August 23, 2010 to August, 27, 2010) on Faculty Induction Training Programme conducted by Education and Educational Management, at National Institute of Technical Teachers’ Training and Research, Chandigarh.

3) Nepali, K., Agarwal A., Kumar, R.*, Banerjee, U. C., Dhar, K. L., Suri, O. P. Design, synthesis and biological evaluation of N-(3-oxo-1,3-diaryl/dihetroarylpropyl)acetamides as potential non-purine xanthine oxidase inhibitors, Abstract published in Med. Chem. Res. 2010, 19, S77. Current Trends in Drug Discovery Research 2010, February 17-21 at Central Drug Research Institute (CDRI),Lucknow. Poster No. 55.

4) Sapra, S., Sandhu, H. S., Chugh, M., Kumar, R.*,Padh, H., Shishoo, C. J., Dhar, K. L. Synthesis and antimalarial activity of arylidene derivatives of Meldrum’s acid, Abstract published in Med. Chem. Res. 2010, 19, S113. Current Trends in Drug Discovery Research 2010, February 17-21 at Central Drug Research Institute (CDRI),Lucknow. Poster No. 117.

5) Kumar, S., Gupta, M., Agarwal A., Kumar, R.*, Banerjee, U. C., Dhar, K. L. Design, syntheisis and xanthine oxidase inhibitory activities of novel 5:6-fused heterocycles, Abstract published in Med. Chem. Res. 2010, 19, S126, Current Trends in Drug Discovery Research 2010, February 17-21 at Central Drug Research Institute (CDRI),Lucknow. Poster No. 139.

6) Kalra, S., Sandhu, H. S., Sapra, S. and Kumar, R.*An account on biological potential of synthetics derivedfrom Meldrum’s acid, Challenges and Opportunities for Pharmacy Graduates in 21stCentuary, Indian Pharmacy Graduates’ Association (IPGA), 2009, November 7-8 at I.S.F. College of Pharmacy, Moga, Punjab, India. Poster No. B24.

7) Singh, P., Gupta, M., Yadav, S. K. and Kumar, R.*Synthetic purines and pyrimidines: recent entries as potential anticancer and antiviral agents, Challenges and Opportunities for Pharmacy Graduates in 21stCentuary, Indian Pharmacy Graduates’ Association (IPGA),2009, November 7-8 at I.S.F. College of Pharmacy, Moga, Punjab, India. Poster No. B25.

8) Kumar, R. Delivered lecture entitled “Design and Synthesis of Novel Ring Expanded Heterocycles and their Corresponding Nucleosides as Potential Chemotherapeutic Agents for Cancer and Viral Diseases” at Indian Institute of Science Education and Research (IISER), 2009, Jan 23. Mohali, India.

9) Kumar, R.Ujjinamatada, R. K. and Hosmane, R. S. The First Synthesis of a Novel 5:7:5-Fused Diimidazodiazepine Ring System and Some of its Chemical Properties, Zing Med. Chem Conference, 2009, Feb 2-4. Playa del Carmen, Mexico.

10) Khathik, G. L. Kumar, R. and Chakraborti, A. K. Co-operative Dual Activation Role of Water in Catalyst-free C-S Bond Formation, National Symposium on New Challenges in Chemistry, 2006, Mar 20 - 21. Guru Nanak Dev University, Amritsar, India Poster No. PP 23.

11) Motiwala, H. F., Kumar, R. and Chakraborti, A. K. Microwave-Assisted Catalyst and Solvent-Free Synthesis of 4-Aminoaryl Derivatives of 4,7-Dichloroquinolines, National Symposium on New Challenges in Chemistry, 2006, Mar 20 - 21. Guru Nanak Dev University, Amritsar, India Poster No. PP 24.

12) KamleshMeena, Kumar, R.PankajSoni, Asit K. Chakaraborti and U.C. Banerjee.Chemoenzymatic synthesis of key precursor of (S)-sotalol, Department of Biotechnology, Punjabi University, Patiala, 21 -22, March, 2006.

13) Kumar, R. and Chakraborti, A. K. An Efficient Protocol for acetal formation under the catalytic influence of Copper (II) Tetrafluoroborate hydrate, National Symposium on Chemistry, 8th CRSI 2006, Mumbai (India).

14) Kumar, R., Thilagavathi, R., Aparna V., Sobhia, M. E., Gopalakrishnan, B. and Chakraborti, A. K. 3-D QSAR Studies on Imidazolyl and N-Pyrrolyl Heptenoates as HMG-CoA Reductase Inhibitors, National Symposium on Chemistry, 7th CRSI 2005, Kolkata (India).

15) Garg, K. S., Kumar, R. and Chakraborti, A. K. Novel Transition Metal Derived Catalyst for Thia-Micheal Reaction. National Symposium on Chemistry, 7th CRSI 2005, Kolkata (India).

16) Chakraborti, A. K., Kondaskar, A., Kumar, R. and Rudrawar, S. Complementarity of Zeolites and Clays in Catalyzing Nucleophilic Opening of Epoxides: Applications for Synthesis of Drug and Drug Intermediates, ICOB-4 & ISCNP-24 (IUPAC International Conference on Biodiversity and Natural Products: Chemistry and Medical Applications), January 2004, Delhi (India) P-165.

17) Chakraborti, A. K., Kaur, G., Sharma, L., Magesh, S. and Kumar, R. Solution and Solid Phase Combinatorial Synthesis of Stilbene Libraries, Biotechnology-A Challenge to Pharmacy Profession, 54thIndian Pharmaceutical Congress, December 2002, Pune (India) B1-27